Bacterial Ribosome
نویسندگان
چکیده
منابع مشابه
Antimicrobial peptides targeting bacterial ribosome
Antibiotics kill bacteria by inhibiting vital enzymes involved in cellular metabolism, including protein production. However, extensive and sometimes gratuitous usage of antibiotics has led to microbial resistance, which is constantly emerging against every antibiotic class, raising serious public health concerns and the urgency for the development of new antibacterial therapeutics. Different s...
متن کاملThe kinetic mechanism of bacterial ribosome recycling
Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome. The translation factors, elongation factor G and ribosome recycling factor, are known to be required for recycling, but there is controversy concerning whether these factors ac...
متن کاملBacterial warfare again targets the ribosome.
In this issue of Structure, Beck and colleagues describe the structure of the Enterobacter cloacae contact-dependent growth inhibition (CDI) toxin in complex with its immunity protein. Further functional studies reveal that CDI targets translation by cleaving 16S ribosomal RNA.
متن کاملStructure and dynamics of bacterial ribosome biogenesis.
Bacterial ribosome biogenesis has been an active area of research for more than 30 years and has served as a test-bed for the development of new biochemical, biophysical and structural techniques to understand macromolecular assembly generally. Recent work inspecting the process in vivo has advanced our understanding of the role of ribosome biogenesis factors, the co-transcriptional nature of a...
متن کاملInteraction of sporangiomycin with the bacterial ribosome.
The peptide antibiotic sporangiomycin specifically inhibits protein synthesis when added to growing cultures of Bacillus subtilis. A study on the reactions for bacterial protein synthesis in cell-free systems has shown that sporangiomycin interferes with specific reactions responsible for peptide-chain elongation, while it has no effect on peptide chain initiation. The primary action of the ant...
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ژورنال
عنوان ژورنال: Bacteriological Reviews
سال: 1970
ISSN: 0005-3678
DOI: 10.1128/mmbr.34.3.228-277.1970